Article

Receptor binding domain of SARS-CoV-2 is a functional αv-integrin agonist

2022-04-11

Abstract excerpt

<h4>ABSTRACT</h4> Among the novel mutations distinguishing SARS-CoV-2 from similar respiratory coronaviruses is a K403R substitution in the receptor-binding domain (RBD) of the viral spike (S) protein within its S1 region. This amino acid substitution occurs near the angiotensin-converting enzyme 2 (ACE2)-binding interface and gives rise to a canonical RGD adhesion motif that is often found in native extracellula...

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Literature Corpus work: 68473bdb-96c4-5b3a-b6f8-18d5c1c7b904
DOI: 10.1101/2022.04.11.487882

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