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Article

Are the integrin binding motifs within SARS CoV-2 spike protein and MHC class II alleles playing the key role in COVID-19?

Frontiers in immunology - 1 Jan 2023

Gerencer Marijan, McGuffin Liam J

Abstract excerpt

The previous studies on the RGD motif (aa403-405) within the SARS CoV-2 spike (S) protein receptor binding domain (RBD) suggest that the RGD motif binding integrin(s) may play an important role in infection of the host cells. We also discussed the possible role of two other integrin binding motifs that are present in S protein: LDI (aa585-587) and ECD (661-663), the motifs used by some other viruses in the course...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37492575
DOI: 10.3389/fimmu.2023.1177691
PMCID: PMC10364474

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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