Article
A numerical investigation into possible mechanisms by that the A629P mutant of ATP7A causes Menkes Disease.
Physical chemistry chemical physics : PCCP - 7 Oct 2010
Kouza Maksim, Gowtham S, Seel Max, Hansmann Ulrich H E
Abstract excerpt
We study in silico possible mechanisms by that the A629P mutant of ATP7A causes Menkes Disease. Our results indicate that the mutation does not have appreciable affects on the stability of copper-bound states but rather destabilizes the characteristic end-to-end β-sheet. In this way, the mutation...
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