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Article

The six metal binding domains in human copper transporter, ATP7B: molecular biophysics and disease-causing mutations.

Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine - 1 Dec 2017

Ariöz Candan, Li Yaozong, Wittung-Stafshede Pernilla

Abstract excerpt

Wilson Disease (WD) is a hereditary genetic disorder, which coincides with a dysfunctional copper (Cu) metabolism caused by mutations in ATP7B, a membrane-bound P1B-type ATPase responsible for Cu export from hepatic cells. The N-terminal part (~ 600 residues) of the multi-domain 1400-residue ATP7B constitutes six metal binding domains (MBDs), each of which can bind a copper ion, interact with other ATP7B domains...

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Identifiers

PMID: 29063292
DOI: 10.1007/s10534-017-0058-2
PMCID: PMC5684295

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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