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Article

Subretinal delivery of AAV5-mediated human Pde6b gene ameliorates the disease phenotype in a rat model of retinitis pigmentosa.

Molecular vision - 1 Jan 2025

Kim Hee Jong, Kwak Ji Hoon, Choi Jun Sub, Kim Jin, Moon Seo Yun, Lee Steven Hyun Seung, Lee Heuiran, Park Keerang, Lee Joo Yong, Won So-Yoon

Abstract excerpt

Purpose: A genetic disorder that affects the beta subunit of cyclic guanosine monophosphate-phosphodiesterase type 6 (PDE6B) in humans leads to autosomal recessive retinitis pigmentosa (RP). This condition causes severe vision loss in early life due to fast deterioration of photoreceptors. This study evaluated the therapeutic potential of subretinal delivery of the adeno-associated virus (AAV)5-mediated human...

Read the complete abstract on PubMed

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Share to Cyclic Nucleotide Phosphodiesterases, Type 6
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40384764
PMCID: PMC12085214

Genes

PDE6B
ERG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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Subretinal delivery of AAV5-mediated human Pde6b gene ameliorates the disease phenotype in a rat model of retinitis pigmentosa.PMID 40384764Read ↗

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