Article

Telomere length of both parents contributes to heritable POT1 cancer-predisposition syndrome

2026-02-11

Abstract excerpt

Germline mutations in POT1 are linked to familial cancer predisposition, and somatic POT1 mutations occur recurrently in tumors. These mutations promote oncogenesis by enabling aberrant telomere elongation. For inherited POT1 mutations, a critical question is the extent to which elongated telomeres are transmitted to the next generation from the POT1 carrier parent and whether the inherited excessively long te...

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Identifiers and source

Literature Corpus work: 672557af-d071-591c-b2c9-39acd5d7c5f8
DOI: 10.64898/2026.02.09.704652

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