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Clinical, genetic, and familial features of POT1 tumor predisposition syndrome.

Cancer - 15 Feb 2026

DiNardo Courtney D, Croden Jennifer, Abdel-Salam Hiam M, Kadia Tapan, Molica Matteo, Bazinet Alexandre, Bose Prithviraj, Maiti Abhishek, Haddad Fadi, Burger Jan, Kantarjian Hagop, Wierda William, Jain Nitin, Ferrajoli Alessandra

Abstract excerpt

BACKGROUND: Protection of telomere 1 (POT1) tumor predisposition syndrome (POT1-TPD) is a hereditary leukemia syndrome that is identified in ∼5% of patients with chronic lymphocytic leukemia (CLL) and is characterized by a predisposition to other cancers, including gliomas, melanomas, and angiosarcomas. This study reports clinical and genetic characteristics of a large cohort of individuals with POT1-TPD....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41686515
DOI: 10.1002/cncr.70315
PMCID: PMC12904310

Genes

POT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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