Article

A method-independent recoverability ceiling for transcript-to-cell assignment in imaging-based spatial transcriptomics

2026-06-22

Abstract excerpt

<title>Abstract</title> <p>In imaging-based spatial transcriptomics, assigning transcripts to their cell of origin underlies most downstream analysis, yet there is no method-independent measure of how accurately it can be recovered. Using synthetic tissue with known ground truth, we compute the best assignment accuracy achievable against the generating process, a ceiling no method can exceed. Calibrated to real d...

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Literature Corpus work: 67178ce7-1890-52b9-80f3-b92e40ccf9f8
DOI: 10.21203/rs.3.rs-10093252/v1

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