Rigor and Reproducibility of Digital Spatial Profiling on Clinically Sourced Human Tissues

Abstract excerpt

<h4>ABSTRACT</h4> Spatial transcriptomic profiling enables precise quantification of gene expression with simultaneous localization of expression profiles onto tissue structures. This new technology promises to improve our understanding of the disease mechanisms. Therefore, there is intense interest in applying these methods in clinical trials or as laboratory developed tests to aid in diagnosis of disease. Befor...

Topics

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• Cancer Genomics and Diagnostics
• Ferroptosis and cancer prognosis
• Gene Expression Profiling
• Phenotype
• Single-cell and spatial transcriptomics
• Technology
• Transcriptome

Identifiers and source

Literature Corpus work

3053247a-7449-5250-8552-7ca60c49a0f4

DOI

10.1101/2024.10.16.618750