Article

AAV-Delivered Anti-PC-OxPL Antibody Fragments: A Novel Therapeutic Approach to Target ALS

2025-01-24

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is characterized by the progressive loss of motor neurons and premature death. The limited understanding of the mechanisms underlying selective motor neuron death has significantly hindered the development of disease-modifying treatments. Ferroptosis, a form of cell death dependent on iron accumulation, has been implicated in the selective degeneration of motor neurons in ALS. O...

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Literature Corpus work: 66b2e224-54cd-5f43-bbbd-261263a032c3
DOI: 10.1101/2025.01.22.634350

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