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Article

Human umbilical vein endothelial cells derived-exosomes promote osteosarcoma cell stemness by activating Notch signaling pathway.

Bioengineered - 1 Dec 2021

Yang Jian, Hu Yong, Wang Lu, Sun Xiangran, Yu Ling, Guo Weichun

Abstract excerpt

Osteosarcoma is one of the most common primary malignant tumors of bone in adolescents. Human umbilical vein endothelial cells (HUVECs) derived exosomes are associated with osteosarcoma cell stemness. Little is known about the function of HUVECs-exosomes in osteosarcoma cell stemness. This work aimed to investigate the mechanism of action of HUVECs-exosomes in regulating stem cell-like phenotypes of osteosarcoma...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 34781817
DOI: 10.1080/21655979.2021.2005220
PMCID: PMC8810022

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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