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The Menin story in acute myeloid leukaemia—The road to success

6 May 2024

Abstract excerpt

The treatment of acute myeloid leukaemia (AML) has changed fundamentally in the last decade with many new targeted therapies entering clinics. Some of the most interesting agents under development are Menin inhibitors which interfere with the interaction of Menin with wild-type (wt) KMT2A or a KMT2A-fusion protein and thereby downregulate the leukaemic gene expression (MEIS1, PBX3, HOX) in NPM1 mutant or...

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PMID: 38710595
DOI: 10.1111/bjh.19508

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