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Article

Health risks and genetic architecture of objectively measured multidimensional sleep health.

Nature communications - 31 Jul 2025

Zhang Shengkui, Zhang Manrui, Yuan Yuxin, Li Zilin, Li Xihao, Li Xiaoyu

Abstract excerpt

A multidimensional sleep health framework improves screening and treatment efficacy by simultaneously addressing multiple sleep domains. However, limited studies have used objective measures to evaluate the co-occurrence of diverse unhealthy sleep characteristics and their pleiotropic health effects. To represent real-world sleep patterns, we introduce the Unfavorable Sleep Profile (USP), an integrated...

Read the complete abstract on PubMed

Topics

Humans
Middle Aged
Adult
Female
Male
Aged
Sleep
Genome-Wide Association Study

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Risk Factors

United Kingdom

Sleep Wake Disorders

Homeodomain Proteins

Polymorphism, Single Nucleotide

Source

Open in PubMed Open full text

Identifiers

PMID: 40745165
DOI: 10.1038/s41467-025-62338-0
PMCID: PMC12313880

Genes

MEIS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 15 Oct 2026.

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