Article

BMAL2 is a druggable target for ARID1A-wildtype ovarian clear cell carcinoma (OCCC)

2025-10-22

Abstract excerpt

Ovarian clear cell carcinoma (OCCC) is highly chemo-resistant and has worse clinical outcome at advanced stages than other ovarian cancer subtypes. The most frequent (∼50%) alterations in OCCC are AT-rich interactive domain 1A gene (ARID1A) mutations which lead to ARID1A deficiency. However, OCCC that retains ARID1A function differs substantially from ARID1A mutated OCCC. Particularly, targeted therapies that sens...

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Literature Corpus work: 65082eca-f4a0-586f-8a9a-f64f573ae33d
DOI: 10.1101/2025.10.21.683700

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