Article

Early life lipid overload in Native American myopathy is phenocopied by <i>stac3</i> knock out in zebrafish

2023-07-29

Abstract excerpt

Understanding the early stages of human congenital myopathies is critical for proposing strategies for improving skeletal muscle performance by the functional integrity of cytoskeleton. SH3 and cysteine-rich domain 3 (Stac3) is a protein involved in nutrient sensing, and is an essential component of the excitation-contraction (EC) coupling machinery for Ca 2+ releasing. A mutation in STAC3 causes debilitating Na...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 64ac6c46-ecfe-5801-8fc0-31065f472c52
DOI: 10.1101/2023.07.26.550753

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Early life lipid overload in Native American myopathy is phenocopied by <i>stac3</i> knock out in zebrafishDOI 10.1101/2023.07.26.550753Read

Early life lipid overload in Native American myopathy is phenocopied by stac3 knock out in zebrafishSemantic proximity Read

Congenital myopathy results from misregulation of a muscle Ca2+ channel by mutant Stac3.Semantic proximity Read

Stac3 is a component of the excitation-contraction coupling machinery and mutated in Native American myopathy.Semantic proximity Read

A novel zebrafish model of <i>SPEG</i> -related centronuclear myopathy (CNM): characterization and comparison with other CNM model zebrafishSemantic proximity Read

Characterization of a novel zebrafish model of SPEG-related centronuclear myopathy.Semantic proximity Read

<i>De Novo</i> Phosphoinositide Synthesis in Zebrafish Is Required for Triad Formation but Not Essential for MyogenesisSemantic proximity Read

Glycerolipid defects in skeletal muscle contribute to rhabdomyolysis in Tango2 deficiencySemantic proximity Read

Stac3 has a direct role in skeletal muscle-type excitation-contraction coupling that is disrupted by a myopathy-causing mutation.Semantic proximity Read

Ca2+ release via two-pore channel type 2 (TPC2) is required for slow muscle cell myofibrillogenesis and myotomal patterning in intact zebrafish embryos.Semantic proximity Read

Autism-associated SHANK3 mutations impair maturation of neuromuscular junctions and striated muscles.Semantic proximity Read

Generation and characterization of a novel gne Knockout Model in ZebrafishSemantic proximity Read

Zebrafish as a model for caveolin-associated muscle disease; caveolin-3 is required for myofibril organization and muscle cell patterningSemantic proximity Read