Article

Endothelial Rbpj is essential for the education of tumour-associated macrophages

2021-12-21

Abstract excerpt

Epithelial ovarian cancer (EOC) is one of the most lethal gynaecological cancers worldwide. EOC cells educate tumour-associated macrophages (TAMs) through CD44-mediated cholesterol depletion to generate an immunosuppressive tumour microenvironment (TME). In addition, tumour cells frequently activate Notch1 receptors on endothelial cells (ECs) to facilitate metastasis. However, little is known whether the endotheli...

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Literature Corpus work: 64a0d388-55d3-58fd-b9ae-6b9e3138d294
DOI: 10.1101/2021.12.20.473423

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