Human genetic variation determines 24-hour rhythmic gene expression and disease risk.

Abstract excerpt

24-hour biological rhythms are essential to maintain physiological homeostasis. Disruption of these rhythms increases the risks of multiple diseases. Biological rhythms are known to have a genetic basis formed by core clock genes, but how individual genetic variation shapes the oscillating transcriptome and contributes to human chronophysiology and disease risk is largely unknown. Here, we mapped interactions...

Topics

• Humans
• Quantitative Trait Loci
• Circadian Rhythm
• Genetic Variation
• Genetic Predisposition to Disease
• Male
• Transcriptome