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Sex-dimorphic and age-dependent organization of 24-hour gene expression rhythms in humans

2 Feb 2023

Abstract excerpt

The circadian clock modulates human physiology. However, the organization of tissue-specific gene expression rhythms and how these depend on age and sex is not defined in humans. We combined data from the Genotype-Tissue Expression (GTEx) project with an algorithm that assigns circadian phases to 914 donors, by integrating temporal information from multiple tissues in each individual, to identify messenger RNA...

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PMID: 36730411
DOI: 10.1126/science.add0846

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