Article
Genome-wide analysis of rare copy number variations reveals PARK2 as a candidate gene for attention-deficit/hyperactivity disorder.
Molecular psychiatry - 1 Jan 2014
Jarick I, Volckmar A-L, Pütter C, Pechlivanis S, Nguyen T T, Dauvermann M R, Beck S, Albayrak Ö, Scherag S, Gilsbach S, Cichon S, Hoffmann P, Degenhardt F, Nöthen M M, Schreiber S, Wichmann H-E, Jöckel K-H, Heinrich J, Tiesler C M T, Faraone S V, Walitza S, Sinzig J, Freitag C, Meyer J, Herpertz-Dahlmann B, Lehmkuhl G, Renner T J, Warnke A, Romanos M, Lesch K-P, Reif A, Schimmelmann B G, Hebebrand J, Scherag A, Hinney A
Abstract excerpt
Attention-deficit/hyperactivity disorder (ADHD) is a common, highly heritable neurodevelopmental disorder. Genetic loci have not yet been identified by genome-wide association studies. Rare copy number variations (CNVs), such as chromosomal deletions or duplications, have been implicated in ADHD and other neurodevelopmental disorders. To identify rare (frequency ≤1%) CNVs that increase the risk of ADHD, we...
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