Article

RABV L protein plays a role in immune escape through its methyltransferase activity

2025-09-12

Abstract excerpt

Viruses in the Mononegavirales order encode a large protein that orchestrates replication, transcription, and the capping of viral RNA. This protein, comprising over 2.000 amino acids, contains an RNA-dependent RNA polymerase, a capping domain, and a methyltransferase (MTase) domain involved in methylating the cap structure. The MTase domain features a conserved K-D-K-E catalytic tetrad -typical of 2′O-methyltran...

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Literature Corpus work: 633c24a0-9a70-5b60-b3a1-eb52fd142d3b
DOI: 10.1101/2025.09.12.675814

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