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Article

First insights into the structural features of Ebola virus methyltransferase activities.

Nucleic acids research - 22 Feb 2021

Valle Coralie, Martin Baptiste, Ferron François, Roig-Zamboni Véronique, Desmyter Aline, Debart Françoise, Vasseur Jean-Jacques, Canard Bruno, Coutard Bruno, Decroly Etienne

Abstract excerpt

The Ebola virus is a deadly human pathogen responsible for several outbreaks in Africa. Its genome encodes the 'large' L protein, an essential enzyme that has polymerase, capping and methyltransferase activities. The methyltransferase activity leads to RNA co-transcriptional modifications at the N7 position of the cap structure and at the 2'-O position of the first transcribed nucleotide. Unlike other...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33503246
DOI: 10.1093/nar/gkaa1276
PMCID: PMC7897494

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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