Article

Two point mutations in protocadherin-1 disrupt Andes hantavirus recognition and afford protection against lethal infection

2022-07-20

Abstract excerpt

Andes virus and Sin Nombre virus are the etiologic agents of severe hantavirus cardiopulmonary syndrome (HCPS) in the Americas for which no FDA-approved countermeasures are available. Protocadherin-1 (PCDH1), a cadherin-superfamily protein recently identified as a critical host factor for ANDV and SNV, represents a new antiviral target; however, its precise role remains to be elucidated. Here, we used computationa...

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Literature Corpus work: 63392038-9691-5208-9b45-33debdd6f0ea
DOI: 10.1101/2022.07.19.500682

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