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Differential tropisms of old and new world hantaviruses influence virulence and developing host-directed antiviral candidates

26 Aug 2025

Abstract excerpt

Hantaviruses are zoonotically transmitted from rodents to humans through the respiratory route, with no currently approved antivirals or widely available vaccines. The recent discovery of interhuman-transmitted Andes virus (ANDV) necessitates the systematic identification of cell tropism, infective potential, and potent therapeutic agents. We utilized human primary lung endothelial cells, various pluripotent stem...

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PMID: 40857262
DOI: 10.1371/journal.ppat.1013401

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