Two point mutations in protocadherin-1 disrupt hantavirus recognition and afford protection against lethal infection

Abstract excerpt

Andes virus (ANDV) and Sin Nombre virus (SNV) are the etiologic agents of severe hantavirus cardiopulmonary syndrome (HCPS) in the Americas for which no FDA-approved countermeasures are available. Protocadherin-1 (PCDH1), a cadherin-superfamily protein recently identified as a critical host factor for ANDV and SNV, represents a new antiviral target; however, its precise role remains to be elucidated. Here, we use...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Mosquito-borne diseases and control
• Share to Viral Infections and Outbreaks Research
• Share to Viral Infections and Vectors