Article

Engineering murine GITRL for antibody-mediated delivery to tumor-associated blood vessels

2020-08-26

Abstract excerpt

<h4>ABSTRACT</h4> Preclinical evidence has suggested that the Glucocorticoid-Induced TNFR-related protein (GITR) may be valuable a target for the development of anticancer therapeutics, but clinical studies with GITR ligand (GITRL) have been disappointing. Here, we report the development of a fusion protein featuring GITR ligand (GITRL) fused to the F8 antibody which targets the alternatively-spliced EDA domain o...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 633287b0-3a31-50c7-8f9c-8e97299bb229
DOI: 10.1101/2020.08.26.268375

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Engineering murine GITRL for antibody-mediated delivery to tumor-associated blood vesselsDOI 10.1101/2020.08.26.268375Read

A high‐affinity human monoclonal antibody specific to the alternatively spliced EDA domain of fibronectin efficiently targets tumor neo‐vasculature <i>in vivo</i>Semantic proximity Read

An Attenuated Targeted-TNF Localizes to Tumors In Vivo and Regains Activity at the Site of Disease.Semantic proximity Read

Different tissue distribution properties for glycosylation variants of fusion proteins containing the p40 subunit of murine interleukin-12.Semantic proximity Read

GcMAF in Radiation Therapy: Identification and Molecular Characterization of the Human GcMAF Receptor<b></b> <b></b>Semantic proximity Read

Secretion of glycosylation site mutants can be rescued by the signal/pro sequence of tissue plasminogen activator.Semantic proximity Read

Construction, affinity maturation, and biological characterization of an anti-tumor-associated glycoprotein-72 humanized antibody.Semantic proximity Read

Fibronectin as target for tumor therapySemantic proximity Read

Optimization strategies for expression of a novel bifunctional anti-PD-L1/TGFBR2-ECD fusion protein.Semantic proximity Read

A novel format for recombinant antibody-interleukin-2 fusion proteins exhibits superior tumor-targeting properties in vivoSemantic proximity Read

Targeted delivery of an antibody-mutant human endostatin fusion protein results in enhanced antitumor efficacy.Semantic proximity Read

Vaccination against the extra domain‐B of fibronectin as a novel tumor therapySemantic proximity Read

Fc-GDF15 glyco-engineering and receptor binding affinity optimization for body weight regulationSemantic proximity Read