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Article

Characterizing regions in the human genome unmappable by next-generation-sequencing at the read length of 1000 bases.

Computational biology and chemistry - 1 Dec 2014

Li Wentian, Freudenberg Jan

Abstract excerpt

Repetitive and redundant regions of a genome are particularly problematic for mapping sequencing reads. In the present paper, we compile a list of the unmappable regions in the human genome based on the following definition: hypothetical reads with length 1 kb which cannot be uniquely mapped with zero-mismatch alignment for the described regions, considering both the forward and reverse strand. The respective...

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Share to Chromosome Duplication
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Repetitive Sequences, Nucleic Acid

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Source

Identifiers

PMID: 25241312
DOI: 10.1016/j.compbiolchem.2014.08.015

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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