Article

Local and global chromatin interactions are altered by large genomic deletions associated with human brain development

2017-08-31

Abstract excerpt

<h4>Background</h4> Large copy number variants (CNVs) in the human genome are strongly associated with common neurodevelopmental, neuropsychiatric disorders such as schizophrenia and autism. Using Hi-C analysis of long-range chromosome interactions, including haplotype-specific Hi-C analysis, and ChIP-Seq analysis of regulatory histone marks, we studied the epigenomic effects of the prominent heterozygous large d...

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Literature Corpus work: 62f8a111-53c3-5e7e-a4c4-f1a4e3ec5196
DOI: 10.1101/182451

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