Article
Impact of copy number variations burden on coding genome in humans using integrated high resolution arrays.
Genetics research - 16 Dec 2014
Veerappa Avinash M, Lingaiah Kusuma, Vishweswaraiah Sangeetha, Murthy Megha N, Suresh Raviraj V, Manjegowda Dinesh S, Ramachandra Nallur B
Abstract excerpt
Copy number variations (CNVs) alter the transcriptional and translational levels of genes by disrupting the coding structure and this burden of CNVs seems to be a significant contributor to phenotypic variations. Therefore it was necessary to assess the complexities of CNV burden on the coding genome. A total of 1715 individuals from 12 populations were used for CNV analysis in the present investigation. Analysis...
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