Article
Feedback activation of EGFR is the main cause for STAT3 inhibition-irresponsiveness in pancreatic cancer cells.
Oncogene - 1 May 2020
Zhao Chengguang, Yang Lehe, Zhou Feng, Yu Yun, Du Xiaojing, Xiang Youqun, Li Chenglong, Huang Xiaoying, Xie Congying, Liu Zhiguo, Lin Jiayuh, Wang Liangxing, Liang Guang, Cui Ri
Abstract excerpt
Pancreatic cancer is one of the world's leading causes of cancer-related death. Activation of STAT3 has been reported as a major contributor in pancreatic cancer tumorigenesis and chemoresistance. However, treatment of advanced pancreatic cancer patients with STAT3 inhibitors often meets drug resistance and heterogeneous response. We found that EGFR activation is a main cause for resistance to STAT3 inhibitors in...
Topics
Join the communities discussing this publication.