Article
Early and effective treatment of KCNQ2 encephalopathy.
Epilepsia - 1 May 2015
Pisano Tiziana, Numis Adam L, Heavin Sinéad B, Weckhuysen Sarah, Angriman Marco, Suls Arvid, Podesta Barbara, Thibert Ronald L, Shapiro Kevin A, Guerrini Renzo, Scheffer Ingrid E, Marini Carla, Cilio Maria Roberta
Abstract excerpt
OBJECTIVES: To describe the antiepileptic drug (AED) treatment of patients with early infantile epileptic encephalopathy due to KCNQ2 mutations during the neonatal phase and the first year of life. METHODS: We identified 15 patients and reviewed the electroclinical, neuroimaging, and AED treatment data. RESULTS: Seizure onset was between 1 and 4 days of age with daily tonic asymmetric, focal and clonic seizures...
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