Article

Q40 sequencing reduces costs and enhances detection of low- frequency somatic variants

2025-09-23

Abstract excerpt

<title>Abstract</title> <p> <bold>Background</bold> High quality scores (Q-scores) are critical for sequencing accuracy, yet the impact of Q40-achieving sequencing technologies (99.99% accuracy) on detecting subtle biological variations remains unvalidated. <bold>Results</bold> Using a comprehensive set of well-established DNA/RNA reference materials (Quartet, NIST-RM8398, SEQC2-HCC1395/BL, MAQC, and ERCC), w...

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Literature Corpus work: 61ed9017-2cd4-59a8-86b5-f236ebd9498d
DOI: 10.21203/rs.3.rs-7283107/v1

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