Article

Cortical organoids reveal human-specific roles of METTL5 in neurodevelopment via regulation of CHCHD2

2025-07-13

Abstract excerpt

METTL5 is a conserved methyltransferase responsible for catalyzing N6-methyladenosine (m 6 A) modification on 18S ribosomal RNA. Human patients with mutations in METTL5 show severe microcephaly and intellectual disability, which has not been fully recapitulated in animal models. Given its emerging role in neurodevelopment, we sought to investigate METTL5 function in a human-specific context using cortical forebr...

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Literature Corpus work: 61e552d9-69b4-5499-be81-821d230005e2
DOI: 10.1101/2025.07.13.664555

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