Article

Pharmacological Inhibition of Cryptochrome and REV-ERB Promotes DNA Repair and Cell Cycle Arrest in Cisplatin-Treated Human Cells

2021-07-30

Abstract excerpt

Nucleotide excision repair (NER) and cell cycle checkpoints impact the ability of the anti-cancer drug cisplatin to inhibit cell proliferation and induce cell death. Genetic studies have shown that both NER and cell cycle progression are impacted by the circadian clock, which has emerged as a novel pharmacological target for the treatment of various disease states. In this study, cultured human cell lines were tre...

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Literature Corpus work: 61c74888-504c-59f3-ae0e-0e81d751f6f4
DOI: 10.21203/rs.3.rs-751809/v1

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