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Topical application of a cryptochrome and REV-ERB inhibitor on human skin increases epidermal <i>XPA</i> and <i>WEE1</i> expression

2026-06-26

Abstract excerpt

The time of day of UV exposure impacts both erythema and cancer development. To investigate whether UV-relevant clock-controlled gene expression can be modulated pharmacologically, we treated human skin explants with a combination of a cryptochoursome inhibitor and REV-ERB antagonist and then examined changes in gene expression of a limited number of core clock and clock-regulated genes. mRNA levels of both the DN...

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Literature Corpus work
ed4edeac-864a-5b2f-ba65-6187d31b7927
DOI
10.64898/2026.06.25.734574
Open publication

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Topical application of a cryptochrome and REV-ERB inhibitor on human skin increases epidermal <i>XPA</i> and <i>WEE1</i> expressionDOI 10.64898/2026.06.25.734574
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