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Clocks, cancer, and chronochemotherapy

31 Dec 2020

Abstract excerpt

The circadian clock coordinates daily rhythmicity of biochemical, physiologic, and behavioral functions in humans. Gene expression, cell division, and DNA repair are modulated by the clock, which gives rise to the hypothesis that clock dysfunction may predispose individuals to cancer. Although the results of many epidemiologic and animal studies are consistent with there being a role for the clock in the genesis...

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PMID: 33384351
DOI: 10.1126/science.abb0738

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