Article

Varigraph: an accurate and widely applicable pangenome graph-based variant genotyper for diploid and polyploid genomes

2025-02-20

Abstract excerpt

Graph pangenome references can address single-reference bias, thereby enhancing the accuracy of variant genotyping and empowering downstream applications in population genetics and quan-titative genetics. However, existing pangenome-based genotyping methods struggle with large or complex pangenome graphs, particularly in polyploid genomes. Here, we introduce Varigraph, an algorithm that leverages the comparison of...

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Literature Corpus work: 61b29947-2f4e-51a5-8977-2be5f1f00171
DOI: 10.1101/2025.02.17.638628

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