Article

Albumin-binding Aptamer Chimeras for Improved siRNA Bioavailability

2021-04-16

Abstract excerpt

Short interfering RNAs (siRNAs) are potent nucleic acid-based drugs designed to target disease driving genes that may otherwise be undruggable with small molecules. However, the potential of administering therapeutic siRNA in vivo is limited by poor pharmacokinetic properties, including rapid renal clearance and nuclease degradation. Nanocarriers have traditionally been explored as means to overcome these challen...

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Literature Corpus work: 61736a7f-1a36-585a-bc94-9caaea953d3c
DOI: 10.1101/2021.04.15.440012

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