Article

Integrated luminescence and phenotypic profiling for drug discovery in a zebrafish model of Marfan syndrome

2026-05-13

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Marfan syndrome (MFS) is a life-threatening heritable connective tissue disorder caused by pathogenic variants in fibrillin-1, characterized by progressive cardiovascular disease. Current medical therapies slow disease progression but do not prevent major complications, underscoring the need for new treatment strategies and unbiased discovery approaches. <h4>Methods</h4> We...

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Literature Corpus work: 61321e3b-27a9-50b9-a49b-1df5ea219f5e
DOI: 10.64898/2026.05.12.722859

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