Article

Systematic disruption of zebrafish fibrillin genes identifies a translational zebrafish model for Marfan syndrome

2025-06-24

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Fibrillins are essential components of the extracellular matrix. Marfan syndrome (MFS), the most common fibrillinopathy, is characterized by severe cardiovascular complications, including cardiac valve abnormalities, myocardial dysfunction, arrhythmias, and, most commonly, thoracic aortic disease. Unfortunately, no definitive medical cure is available. <h4>Objectives</h4> T...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e6f3deeb-bff1-5aaf-ac32-51f9b01daec9
DOI: 10.1101/2025.06.21.659830

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Systematic disruption of zebrafish fibrillin genes identifies a translational zebrafish model for Marfan syndromeDOI 10.1101/2025.06.21.659830Read

Integrated luminescence and phenotypic profiling for drug discovery in a zebrafish model of Marfan syndromeSemantic proximity Read

CRISPR/Cas9 in zebrafish: An attractive model for FBN1 genetic defects in humans.Semantic proximity Read

The molecular genetics of Marfan syndrome and related disordersSemantic proximity Read

Development of a zebrafish model of Loeys-Dietz syndrome through tgfbr2b knockdown.Semantic proximity Read

The aorta in Marfan syndrome: from molecular mechanisms to mechanobiological dysfunction.Semantic proximity Read

Therapeutic management of patients with Marfan syndrome: focus on cardiovascular involvement.Semantic proximity Read

Marfan syndrome revisited: From genetics to the clinic.Semantic proximity Read

Recent progress towards a molecular understanding of Marfan syndrome.Semantic proximity Read

Pathophysiology and Management of Cardiovascular Manifestations in Marfan and Loeys–Dietz SyndromesSemantic proximity Read

Marfan syndrome.Semantic proximity Read

A Marfan-Associated FBN1 Nonsense Mutation Mouse Model Reveals Adventitial Inflammation During Aneurysm ProgressionSemantic proximity Read

Genetic models of fibrillinopathies.Semantic proximity Read