Article

Pharmacodynamic Profile of a Recombinant ADAMTS13 (BAX930) in Hereditary Thrombotic Thrombocytopenic Purpura (Upshaw-Schulman Syndrome (USS))

2016-12-02

Abstract excerpt

Abstract Introduction The plasma metalloprotease, ADAMTS13, regulates the size of VWF multimers by cleaving VWF at Tyr1605-Met1606 in the A2 domain. A recombinant ADAMTS13 (rADAMTS13, BAX930), manufactured using a plasma-free method, may provide an important alternative replacement therapy for patients with ADAMTS13 deficiencies, such as hereditary thrombotic thrombocytopenic purpura (hTTP). In contrast to plasma...

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Literature Corpus work: 60ec3f5b-c0b2-5dfa-a414-8b765f44c809
DOI: 10.1182/blood.v128.22.135.135

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