Article

Investigation into the silencing of heterochromatin in mammalian cells

2016-01-01

Abstract excerpt

Much of the mammalian genome is composed of repetitive elements, consisting of tandem and interspersed repeats. Heterochromatinisation of pericentromeric tandem satellite repeats plays an important role in centromere formation and maintenance of genome stability. Additionally, several human diseases are caused by microsatellite repeat expansion. Among different classes of interspersed repeats, retro-elements LINEs...

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Literature Corpus work: 60dbc8f6-3156-5090-95ec-07941e13ea2a
DOI: 10.25560/58329

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