Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Translating HDAC inhibitors in Friedreich’s ataxia

21 Jul 2016

Abstract excerpt

Introduction: Friedreich ataxia (FRDA) is an autosomal recessive neurodegenerative disease caused by expansion of a GAA·TTC triplet in the first intron of the FXN gene, encoding the essential mitochondrial protein frataxin. Repeat expansion results in transcriptional silencing through an epigenetic mechanism, resulting in significant decreases in frataxin protein in affected individuals. Areas covered: We review...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amyotrophic Lateral Sclerosis Research
Share to Genetic Neurodegenerative Diseases
Share to Histone Deacetylase Inhibitors Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 28392990
DOI: 10.1080/21678707.2016.1215910

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Translating HDAC inhibitors in Friedreich’s ataxiaPMID 28392990Read ↗

Increasing frataxin gene expression with histone deacetylase inhibitors as a therapeutic approach for Friedreich's ataxiaSemantic proximity Read ↗

Rationale for the development of 2-aminobenzamide histone deacetylase inhibitors as therapeutics for Friedreich ataxia.Semantic proximity Read ↗

Epigenetic therapy for <scp>F</scp> riedreich ataxiaSemantic proximity Read ↗

Prolonged treatment with pimelic o-aminobenzamide HDAC inhibitors ameliorates the disease phenotype of a Friedreich ataxia mouse model.Semantic proximity Read ↗

Histone deacetylase inhibitors reverse gene silencing in Friedreich's ataxia.Semantic proximity Read ↗

Two New Pimelic Diphenylamide HDAC Inhibitors Induce Sustained Frataxin Upregulation in Cells from Friedreich's Ataxia Patients and in a Mouse ModelSemantic proximity Read ↗

Transcriptional profiling of isogenic Friedreich ataxia induced pluripotent stem cell-derived neuronsSemantic proximity Read ↗

Inhibition of the SUV4-20 H1 histone methyltransferase increases frataxin expression in Friedreich’s ataxia patient cellsSemantic proximity Read ↗

Epigenetic and neurological effects and safety of high-dose nicotinamide in patients with Friedreich's ataxia: an exploratory, open-label, dose-escalation studySemantic proximity Read ↗

HDAC Inhibitors Correct Frataxin Deficiency in a Friedreich Ataxia Mouse ModelSemantic proximity Read ↗

Pathophysiogical and therapeutic progress in Friedreich ataxia.Semantic proximity Read ↗

From Genetic Mutation to Therapy in Friedreich Ataxia: Molecular Mechanisms, Therapeutic Advances, and Translational ChallengesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.