Article

Epigenetic transcriptional regulation in Friedreich's Ataxia

2017-01-01

Abstract excerpt

The Frataxin gene is pathologically partially silenced causing the neurodegenerative disorder, Friedreich's Ataxia (FRDA). The occurrence of the GAA trinucleotide expansion within intron 1 has been shown to invoke several epigenetic mechanisms associated with gene silencing. In this thesis I have investigated the effect on the pathological silencing of frataxin through alteration of potential key regulators of gen...

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Literature Corpus work: 187f3605-a779-5aa1-93a7-dfdeb61cd286
DOI: 10.25560/75489

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