Article

Heterochromatin effects in Friedreich's ataxia and sexual dimorphism

2012-01-01

Abstract excerpt

Heterochromatin is implicated in the negative regulation of gene expression. To understand the effects of heterochromatin on RNA polymerase-II (RNAPII) mediated transcription, this study focused on the FXN gene where abnormal silencing induced by expanded (GAA)n repeats causes Friedreich's ataxia (FRDA), an incurable neurological disorder. Here, the silenced FXN locus was found to be modified by the heterochromati...

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Literature Corpus work: 4d25f60c-85df-52a1-a1d4-3bb2a6cf0e81
DOI: 10.25560/9644

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