Article

Genome-wide association study analysis of disease severity in Acne reveals novel biological insights

2023-11-14

Abstract excerpt

Acne vulgaris is a common skin disease that affects >85% of teenage young adults among which >8% develop severe lesions that leaves permanent scars. Genetic heritability studies of acne in twin cohorts have estimated that the heritability for acne is 80%. Previous genome-wide association studies (GWAS) have identified 50 genetic loci associated with increased risk of developing acne when compared to healthy indivi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 60be2895-ad89-5486-9897-0a6486f15640
DOI: 10.1101/2023.11.13.23298473

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Genome-wide association study analysis of disease severity in Acne reveals novel biological insightsDOI 10.1101/2023.11.13.23298473Read

Genome-wide association meta-analysis identifies 29 new acne susceptibility loci.Semantic proximity Read

What does acne genetics teach us about disease pathogenesis?Semantic proximity Read

Genome-wide meta-analysis identifies novel loci conferring risk of acne vulgaris.Semantic proximity Read

Two new susceptibility loci 1q24.2 and 11p11.2 confer risk to severe acne.Semantic proximity Read

Genome-wide association meta-regression identifies stem cell lineage orchestration as a key driver of acne riskSemantic proximity Read

Heritability and GWAS Analyses of Acne in Australian Adolescent Twins.Semantic proximity Read

Genome-wide meta-analysis implicates mediators of hair follicle development and morphogenesis in risk for severe acneSemantic proximity Read

Exploring Genetic Drug Targets in Acne Vulgaris: A Comprehensive Proteome‐Wide Mendelian Randomization StudySemantic proximity Read

Genetic architecture of acne vulgarisSemantic proximity Read

Genome-wide association study of skin complex diseases.Semantic proximity Read

The Inflammatory Basis of Acne Pathogenesis.Semantic proximity Read

Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.Semantic proximity Read