Article
Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.
Nature communications - 13 Jun 2014
Navarini Alexander A, Simpson Michael A, Weale Michael, Knight Jo, Carlavan Isabelle, Reiniche Pascale, Burden David A, Layton Alison, Bataille Veronique, Allen Michael, Pleass Robert, Pink Andrew, Creamer Daniel, English John, Munn Stephanie, Walton Shernaz, Willis Carolyn, Déret Sophie, Voegel Johannes J, Spector Tim, Smith Catherine H, Trembath Richard C, Barker Jonathan N
Abstract excerpt
Acne vulgaris (acne) is a common inflammatory disorder of the cutaneous pilo-sebaceous unit. Here we perform a genome-wide association analysis in the United Kingdom, comparing severe cases of acne (n=1,893) with controls (n=5,132). In a second stage, we genotype putative-associated loci in a further 2,063 acne cases and 1,970 controls. We identify three genome-wide significant associations: 11q13.1 (rs478304,...
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