Back to search

Article

Preclinical efficacy and safety of Tegavivint in Wnt-activated hepatocellular carcinoma

2026-07-16

Abstract excerpt

<h4>Background & Aims</h4> Hepatocellular carcinoma (HCC), a predominant form of liver cancer, remains a significant clinical unmet need. Given that 30–50% of HCC cases harbour mutations in the Wnt/β-catenin signalling pathway, targeting this cascade represents a promising therapeutic strategy. However, the clinical translation of Wnt inhibitors has been hindered by severe adverse events observed in preclinical m...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
60bb969b-9f41-50a4-9e4d-26a492057359
DOI
10.64898/2026.07.14.738585
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Preclinical efficacy and safety of Tegavivint in Wnt-activated hepatocellular carcinomaDOI 10.64898/2026.07.14.738585
Downregulation of PD-L1 expression by Wnt pathway inhibition to enhance PD-1 blockade efficacy in hepatocellular carcinomaSemantic proximity
Wnt/β-Catenin Signaling in Liver CancersSemantic proximity
The Wnt signaling pathway in hepatocellular carcinoma: Regulatory mechanisms and therapeutic prospectsSemantic proximity
Atractylenolide III predisposes miR-195-5p/FGFR1 signaling axis to exert tumor-suppressive functions in liver cancerSemantic proximity
Effective therapeutic targeting of CTNNB1-mutant hepatoblastoma with WNTinib.Semantic proximity
Targeting the NOTCH2/ADAM10/TCF7L2 Axis‐Mediated Transcriptional Regulation of Wnt Pathway Suppresses Tumor Growth and Enhances Chemosensitivity in Colorectal CancerSemantic proximity
Small molecule antagonists of Tcf4/β‐catenin complex inhibit the growth of HCC cells <i>in vitro</i> and <i>in vivo</i>Semantic proximity
On target? Strategies and progress in the development of therapies for colorectal cancer targeted against WNT signalling.Semantic proximity
A Novel Liver Cancer-Selective Histone Deacetylase Inhibitor Is Effective Against Hepatocellular Carcinoma and Induces Durable Responses with ImmunotherapySemantic proximity
β-Sitosterol Suppresses Hepatocellular Carcinoma Growth and Metastasis via FOXM1-Regulated Wnt/β-Catenin PathwaySemantic proximity
Targeting the WNT Signaling Pathway in Cancer TherapeuticsSemantic proximity
Wnt Signaling in Liver CancerSemantic proximity
Select a neighboring publication to make it the new centre.