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Human Myeloperoxidase-Driven Activation of Skin Sensitizing p-Phenylenediamine-related Aromatic Diamines and Phenylpropanoids – Insights from In Chemico and In Silico Approaches

2026-07-17

Abstract excerpt

<title>Abstract</title> <p> Skin sensitization is initiated by the covalent binding of low-molecular-weight chemicals to skin proteins. For prehaptens, this requires oxidative activation to generate protein-reactive electrophiles. While abiotic oxidation is established, enzymatic oxidation remains poorly understood. Because neutrophils infiltrate the skin during the induction phase of sensitization and release t...

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Literature Corpus work: 608c0ed3-b5d8-56d6-844a-a5a421b07a36
DOI: 10.21203/rs.3.rs-10281038/v1

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Human Myeloperoxidase-Driven Activation of Skin Sensitizing p-Phenylenediamine-related Aromatic Diamines and Phenylpropanoids – Insights from In Chemico and In Silico ApproachesDOI 10.21203/rs.3.rs-10281038/v1Read

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