Monogenic and polygenic determinants of sarcoma risk: an international genetic study.

doi:10.1016/S1470-2045(16)30147-4

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Article

Monogenic and polygenic determinants of sarcoma risk: an international genetic study.

The Lancet. Oncology - 1 Sept 2016

Ballinger Mandy L, Goode David L, Ray-Coquard Isabelle, James Paul A, Mitchell Gillian, Niedermayr Eveline, Puri Ajay, Schiffman Joshua D, Dite Gillian S, Cipponi Arcadi, Maki Robert G, Brohl Andrew S, Myklebost Ola, Stratford Eva W, Lorenz Susanne, Ahn Sung-Min, Ahn Jin-Hee, Kim Jeong Eun, Shanley Sue, Beshay Victoria, Randall Robert Lor, Judson Ian, Seddon Beatrice, Campbell Ian G, Young Mary-Anne, Sarin Rajiv, Blay Jean-Yves, O'Donoghue Seán I, Thomas David M

Abstract excerpt

BACKGROUND: Sarcomas are rare, phenotypically heterogeneous cancers that disproportionately affect the young. Outside rare syndromes, the nature, extent, and clinical significance of their genetic origins are not known. We aimed to investigate the genetic basis for bone and soft-tissue sarcoma seen in routine clinical practice. METHODS: In this genetic study, we included 1162 patients with sarcoma from four...

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PMID: 27498913
DOI: 10.1016/S1470-2045(16)30147-4

Genes

ATM
ATR
BRCA2
ERCC2

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