Article

Unprecedentedly efficient CUG initiation of an overlapping reading frame in <i>POLG</i> mRNA yields novel protein POLGARF

2020-03-08

Abstract excerpt

While near cognate codons are frequently used for translation initiation in eukaryotes, their efficiencies are usually low (<10% compared to an AUG in optimal context). Here we describe a rare case of highly efficient near cognate initiation. A CUG triplet located in the 5’ leader of POLG mRNA initiates almost as efficiently (~60-70%) as an AUG in optimal context. This CUG directs translation of a conserved 260 t...

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Identifiers and source

Literature Corpus work: 60296cd3-2734-5868-895b-f20e6c157f9b
DOI: 10.1101/2020.03.06.980391

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